ULK1 and neoplasm: Unlike the increased phosphorylation of Ulk1, both LCI and LCII diminish dramatically in Tet2-deficient mouse livers (Fig. 1g), which is confirmed in TET2 KO tumor cells (Supplementary Fig. S1j), suggesting that Tet2 might promote activation of autophagy in both mTORC1-dependent and -independent manners.