双氢青蒿素(Dihydroartemisinin, DHA)是青蒿素的衍生物,具有抗疟、免疫调节作用及抗肿瘤活性,并可通过调节AMPK-mTOR-p70S6k途径激活自噬,介导AML细胞铁死亡[13]。一种植物提取物香蒲新苷(Typhaneoside)也可通过AMPK-mTOR途径在AML中诱导自噬介导的铁死亡,抑制自噬后可恢复细胞活力[14]。. Here, RPS6KB1 is linked to acute myeloid leukemia.