MARK4 overexpression hyperphosphorylates the microtubule-associated protein Tau, which causes its detachment from microtubules and eventually develops neurofibrillary tangles, a pathogenic hallmark of Alzheimer’s disease (Jenkins and Johnson, 2000; Trinczek et al., 2004; Lee et al., 2012). Here, MARK4 is linked to early-onset autosomal dominant Alzheimer disease.