HGF activation induces integrin clustering, the recruitment of FAK and paxillin, and the transduction of downstream MAPK, PI3K, and Rho GTPase pathways which are important in cancer cell growth, invasion, and metastasis (Lai et al, 2000; Liu et al, 2002; Ishibe et al, 2003, 2004). The gene discussed is HGF; the disease is cancer.