ATG5 and Parkinson disease: Moreover, ATG5 knockout in microglia caused PD-like motor and cognitive dysfunction, and induced neuronal damage, increased the production of pro-inflammatory mediators, as well as promoted NLRP3 inflammasome activation and PDE10A expression in the striatum of mice, while inhibition of NLRP3 using MCC950 rescued microglia activation and neuronal loss [51].