NLRP3 and Parkinson disease: NLRP3 gene knockout decreased pro-inflammatory cytokines secretion and Caspase1 expression, improved nigral autophagy, that manifested by an increase in LC3-II expression and a decrease in p62 level, and suppressed nigral dopaminergic degeneration, striatal dopamine (DA) deletion, glial activation and nigral α-synuclein aggregation in chronic MPTP-treated PD mice [50].