Additionally, autophagic inhibitor 3-MA treatment worsened ethanol-induced memory impairment, while autophagy activation with rapamycin suppressed IL-1β and IL-18 genes transcription and NLPR3, pro-Caspase-1 and Caspase-1 proteins expression in ethanol-induced microglia and mice [19]. Here, CASP1 is linked to memory impairment.