Taken together, the results of in vitro and in vivo models of PD indicate that autophagy interacts with NLRP3 inflammasome, and the enhancement of autophagy in microglia might inactivate NLRP3 inflammasome, thus inhibiting the production of pro-inflammatory mediators to alleviate the symptoms of PD. This evidence concerns the gene NLRP3 and Parkinson disease.