Abnormal α-synuclein (α-Syn) deposition and spreading comprise a common denominator in a wide range of neurodegenerative disorders, collectively termed synucleinopathies, including Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB) [1, 2]. The gene discussed is SNCA; the disease is Parkinson disease.