SQSTM1 and Parkinson disease: More specifically, intravenous administration or stereotactic injection of exosomes containing aberrant forms of α-Syn, isolated from either brain tissue [22], serum [21], or blood plasma [20] from synucleinopathy patients (PD, DLB, or both), was able to induce intracellular protein accumulation, characterized by the presence of phos-phorylated proteins, such as p-α-Syn, pTau, p62, and ubiquitin, as well as microglia activation [20, 23].