Solutions based on inhibition of the expression of this protein have proven beneficial in the negative regulation of tumour growth through the Rif1-hTERT or Rif1-PP1/AXIN- Wnt/β-catenin interaction pathways, and it is therefore believed that further research into Rif1 in tumorgenesis may provide many effective solutions for cancer therapy [45]. The gene discussed is AXIN1; the disease is neoplasm.