ACSL5 and neoplasm: Another mitochondrial enzyme, acyl-CoA synthetase long-chain family member 5 (ACSL5), is responsible for converting free long-chain fatty acids with 16-18 carbons, including oleic acid, linoleic acid, and palmitic acid, into fatty acyl-coenzyme A. ACSL5 has been implicated in pro-apoptosis and tumor growth prevention in cancer [80].