Ineffective chemotherapy can cause tumor growth during the NAT period and disturb a radical resection with a sufficient circumferential margin, which is essential to prevent postoperative local recurrence.31,32 To evaluate SELENBP1 expression before treatment may contribute to screening out patients who will respond poorly to 5-fluorouracil + oxaliplatin chemotherapy and support the choice of other regimens. Here, SELENBP1 is linked to neoplasm.