For years, SELENBP1 has been in the spotlight as a tumor suppressor protein.21–25 In human cancer tissue, decreased SELENBP1 expression is correlated with poor prognosis in several types of cancer, including lung,25 prostate,23 and colorectal carcinoma.26 These reports support our findings in the present study. This evidence concerns the gene SELENBP1 and colorectal carcinoma.