The final multivariate logistic regression model including MZ B cells percentage and IgA levels at diagnosis as immunological covariates and the CT evidence of consolidations in the lower fields and mediastinal lymph nodes enlargement, allowed us to reach a better predictive performance for GL-ILD treatment (sensitivity 87.50% and specificity 76.92%, using a cut-off value of 0.5). Here, CD79A is linked to interstitial lung disease.