When comparing serum BDNF concentrations between males with obesity (mean ± SD; 24,301 ± 6,195 pg/mL) and normal-BMI males (mean ± SD; 20,906 ± 6,343 pg/mL), statistical significance was not detected (p = 0.147) (Fig. 1). The gene discussed is BDNF; the disease is obesity due to melanocortin 4 receptor deficiency.