INS and obesity due to melanocortin 4 receptor deficiency: Participants with obesity also demonstrated statistically significant higher measures of weight (p < 0.001), BMI (p < 0.001), BMI z-score (p < 0.001), triglycerides (p < 0.001), systolic, diastolic and mean arterial BP (p < 0.001), insulin AUC (p = 0.002), waist circumference (p < 0.001), hip circumference (p < 0.001), waist-to-hip ratio (p = 0.03), and waist-to-height ratio (p < 0.001).