In the cortex (Fig. 3f), we also observed significant main effects of both genotype (F1,27 = 247.2, P < 0.0001) and diet (F1,27 = 64.67, P < 0.0001) for TNFα, with 3xTg-AD mice and the Ch− mice exhibiting elevations. Here, TNF is linked to Alzheimer disease.