A total of 259 ferroptosis-related genes were obtained from FerrDb database, and 4 common genes of puerarin, ferroptosis, and osteoarthritis were obtained by overlapping the genes obtained in “Targets of puerarin” and “Differentially expressed genes in OA,” namely PLIN2, PTGS2, VEGFA, and IL6, as shown in Fig. 2C. This evidence concerns the gene PLIN2 and osteoarthritis.