ATP1A3 and Parkinson disease: Autosomal-dominant missense mutations leading to loss of function in ATP1A3 cause movement disorders such as rapid-onset dystonia parkinsonism and childhood alternating hemiplegia (recurrent paralysis on one side) in humans (de Carvalho Aguiar et al., 2004; Heinzen et al., 2012; Heinzen et al., 2014), while loss-of-function mutations in Atp1a3 result in generalised seizures and locomotor abnormalities, including hyperactivity, in mice, which was not observed in zebrafish (Clapcote et al., 2009; Hunanyan et al., 2015; Ikeda et al., 2013; Kirshenbaum et al., 2011; Sugimoto et al., 2014).