DMC1 and cancer: This finding parallels previous observations that the RAD-54.B ortholog Rdh54/Tid1 is required to inhibit the association of meiotic recombinase Dmc1 with unbroken DNA during S. cerevisiae meiosis (45) and that both RAD-54.B and RAD-54.L orthologs contribute to antagonizing unproductive RAD51 accumulation and associated toxicity when RAD51 is overexpressed in vegetative yeast cells or cancer cells (43,44).