This explanation is based on some previous reports that a higher proportion of PD‐L1 positive tumor cells was observed in high TMB tumors22 and that TMB was associated with PD‐L1 tumor cell staining using the IHC assay (PD‐L1 E1L3N XP Rabbit mAb, Cell Signaling Technology) > 20%,23 and that high TMB is associated with poor outcomes for targeted therapy in EGFR‐mutated lung cancer.24 This evidence concerns the gene EGFR and lung carcinoma.