Furthermore, previous studies have shown that CD40 stimulation could induce strong systemic anti-tumor responses leading to regression of tumors in preclinical models (van Mierlo et al., 2002; Sandin et al., 2014), and it has also been shown to synergize with CBT (Westcott et al., 2021; Morrison et al., 2020). The gene discussed is CD40; the disease is neoplasm.