Moreover, to investigate the mechanisms mediating the effects of tempol in sepsis, we quantified plasma and renal tissue levels of a marker of lipid peroxidation (malondialdehyde [MDA]) and its counter‐regulatory NRF2‐dependent system, along with markers of inflammation (tumor necrosis factor alpha [TNF‐α]) and counter‐inflammation (interleukin‐10 [IL‐10]). The gene discussed is IL10; the disease is Sepsis.