However, RAT prevented sepsis‐induced overexpression of cortical tissue tumor necrosis factor alpha (TNF‐α; 51 ± 16% decrease; p = 0.003) and medullary Thr‐495 phosphorylation of endothelial nitric oxide synthase (eNOS; 63 ± 18% decrease; p = 0.015). The gene discussed is NOS3; the disease is Sepsis.