In addition, we identified 20 hub genes CDK1, CDC20, CCNA2, BUB1B, BUB1, CCNB1, MAD2L1, AURKB, PLK1, CCNB2, NCAPG, KIF11, CDCA8, AURKA, KIF2C, NDC80, CDC6, CDC45, ASPM and DLGAP5 in the MEbrown module associated with psoriasis. The gene discussed is CDC45; the disease is psoriasis.