This is consistent with the recent identification of MRP1 as a direct ATP-dependent cGAMP exporter that can regulate intrinsic activation of STING.25 Because export of cGAMP limits STING activation, a deficiency in MRP1 leads to enhanced cGAS-dependent autoimmunity in a mouse model of Aicardi-Goutières syndrome. The gene discussed is CGAS; the disease is Autoimmunity.