Clinically, it was reported that, unlike heparanase, Hpa2 expression is readily detected in normal epithelium of the bladder, breast, cervical, gastric, and ovarian tissues, whereas its expression is substantially decreased in the resulting carcinomas,10, 108, 109, 110, 111, 112 expression pattern that is typical of a tumor suppressor. This evidence concerns the gene HPSE and neoplasm.