In order to study mechanisms underlying the role of HSP90AA1 in LM of HNSCC, we analyzed the expression profile and clinical data of HSP90AA1 in 419 cases of HNSCC (including 270 cases with LM and 149 cases without LM) and 44 cases of normal tissues from the TCGA database. This evidence concerns the gene HSP90AA1 and head and neck squamous cell carcinoma.