On the other hand, the role that eHSP90 plays in regulating tumor cell motility and enhancing metastatic potential has been reported, including increased cell adhesion and motility through integrin-mediated signaling [43], enhanced cell invasion through binding with HER2 and ErB3 [44], and increased cell invasion through actin rearrangement [45]. This evidence concerns the gene ERBB2 and neoplasm.