AQP4 and tTau were still independent predictors of CSO-EPVS numbers after adjusting for different MRI protocols and cardiovascular risk factors (β = 0.28, SE = 0.13, p = 0.040; β = 0.35, SE = 0.15, p = 0.021, respectively). The gene discussed is AQP4; the disease is craniosynostosis.