WB analysis showed that LDHA was significantly up-regulated and LDHB was down-regulated in the seven pairs of ccRCC than their non-cancerous specimens (P < 0.001, P < 0.001, respectively, Fig. 2C), which was consistent with GEPIA2 and ULACAN analyses. The gene discussed is LDHB; the disease is nonpapillary renal cell carcinoma.