CD4 and cancer: TIMER2 analysis displayed that LDHB gene expression was significantly associated with infiltration of seven TIIC subsets, i.e., B cell (rho = 0.109, P = 0.019), cancer-associated fibroblast (rho = −0.116, P = 0.013), CD4+ T cell (rho = 0.411, P < 0.001), CD8+ T cell (rho = −0.249, P < 0.001), endothelial cell (rho = −0.234, P < 0.001), macrophage (rho = 0.247, P = 0.001), and neutrophil (rho = 0.167, P < 0.001), except dendritic cell (rho = 0.021, P = 0.651) in the 533 ccRCC samples (Fig. 4).