As for LDHB, its reduced expression (<6 scores) was significantly associated with tumor grade (P < 0.001, Pearson chi-square test), stage (P < 0.001, Fisher’s exact test, Fig. S2A), size (P = 0.001, Pearson chi-square test), metastasis (P = 0.001, Fisher’s exact test), and survival rate (P < 0.001, Fisher’s exact test), instead of patients’ sex or age (P = 0.618, P = 0.111, respectively, Pearson chi-square test). The gene discussed is LDHB; the disease is neoplasm.