There was also a tight connection between LDHA and infiltration of TIICs, including B cell (rho = 0.129, P = 0.006), cancer-associated fibroblast (rho = −0.150, P = 0.001), CD4+ T cell (rho = −0.201, P < 0.001), CD8+ T cell (rho = −0.243, P < 0.001), endothelial cell (rho = 0.136, P = 0.003), dendritic cell (rho = 0.162, P < 0.001), and neutrophil (rho = 0.164, P < 0.001), except macrophage (rho = 0.086, P = 0.066) in the same ccRCC samples (Fig. S3). Here, CD8A is linked to cancer.