NUCB1 and cancer: Figure 2A only showed a part of them. After preliminary screening, six molecules were identified, namely APC, CAV-1, CTNNB1, MMP7, NUCB1, and DUSP1. Owing to the fact that the correlation between NUCB1 and COX-2 in colorectal adenocarcinoma has not been reported, we finally locked on NUCB1 (Fig. 2B predicts the correlation between COX-2 and NUCB1). The UALCAN database showed that the expression of NUCB1 was decreased in cancer tissues of stages I to IV, suggesting that NUCB1 was a negative regulatory molecule, probably (Figs. 1C and 1D, P < 0.01).