NRP1 and melanoma: It is a key balance in the angiogenic switch can bind to transmembrane receptors displayed by endothelial cells, thereby inducing inhibition of angiogenic signaling (Kazerounian, Yee & Lawler, 2008), has been shown in previous  in vitro and in vivo studies to inhibit melanoma progression in a variety of ways (Trotter, Colwell & Tron, 2003).