In addition, TGF-β signaling pathway, epithelial-to-mesenchymal transition (EMT) and angiogenesis-related pathways are enriched by fibroblast subpopulations and TGF-β 1 is an important mediator of renal fibrosis after renal transplantation (Campistol et al., 2001). Here, TGFB1 is linked to renal fibrosis.