TARDBP, SQSTM1, VCP, FUS, TBK1, MAPT, GRN, CHCHD10 and especially C9orf72 are recognized as critical genetic players in the development of ALS-FTD spectrum disorders (Burrell et al., 2011; Gentile et al., 2019). The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.