In particular, missense changes in the mitochondrial protein CHCHD10 have been detected in few patients presenting heterogenous and complex clinical phenotypes including ALS-FTD (Ronchi et al., 2015; Gentile et al., 2019), pure ALS, flail-arm syndrome (Bannwarth et al., 2014) and CMT2 (Auranen et al., 2015). The gene discussed is CHCHD10; the disease is amyotrophic lateral sclerosis.