NPPB and congestive heart failure: In the isoproterenol-induced chronic heart failure rat model, the left ventricular peak pressure (LVSP) and the maximum increase rate of left ventricular isovolumic systolic pressure (+dp/dtmax) are significantly increased in the total ginsenosides (TGS) and berberine combined group, while the left ventricular end-diastolic pressure (LVEDP), plasma BNP and cardiomyocyte Ca2+ concentrations are significantly decreased.