In this research, using Paquinimod (Talley et al., 2021; Zhao et al., 2021; Su et al., 2022) (Paq, also known as ABR25757), an S100A8/A9 specific inhibitor which prevents S100A8/A9 to bind to TLR4, we explored the role of S100A9 in the development of septic AKI in a murine model of cecal ligation and puncture (CLP)-induced sepsis. The gene discussed is S100A9; the disease is acute kidney injury.