ACE and diabetes mellitus: Dose-related risk of volume depletion adverse events was identified among various conditions, such as subjects with low baseline eGFR (<60 ml/min/1.73 m2), concomitant use of ACE inhibitors or ARB (with twofold increase of volume depletion events), concomitant use of diuretic, ≥65 years of age, >7.9% baseline HbA1c, ≤110 mmHg systolic blood pressure, diabetic complications, and ≥10 years’ duration of diabetes.