Recently, the diagnostic utility of galectin-1 and galectin-3, alone or in combination with TPO, HBME-1 (Hector Battifora Mesothelial-1), and CK19 (cytokeratin 19), in benign and malignant TNs, was investigated to determine the utility of each marker or their combination for the accurate and reliable preoperative diagnosis of thyroid cancer (163). Here, LGALS3 is linked to thyroid cancer.