Recently, the diagnostic utility of galectin-1 and galectin-3, alone or in combination with TPO, HBME-1 (Hector Battifora Mesothelial-1), and CK19 (cytokeratin 19), in benign and malignant TNs, was investigated to determine the utility of each marker or their combination for the accurate and reliable preoperative diagnosis of thyroid cancer (163). This evidence concerns the gene LGALS3 and thyroid gland carcinoma.