The innate circadian clock functions as a commander to coordinate physiological processes, like immunity, metabolism, and inflammation (Shivshankar et al., 2020) Disruption of the clock could be a risk for multiple outcomes, like obesity, diabetes, hyperlipidemia, cancer, and so on (Neves et al., 2022). This evidence concerns the gene CLOCK and obesity due to melanocortin 4 receptor deficiency.