Ota et al. (2022) found that ALPS-index was significantly correlated with deposition of abnormal protein (Aβ and tau) in bilateral temporal lobe cortex, left and right parietal lobe cortex and posterior cingulate gyrus. Another study considered the effect of AD-related gray matter ratio, and still found ALPS-index was a significant mediator of the relationship between abnormal protein deposition and cognitive impairment in multiple brain regions (Hsu et al., 2023). This evidence concerns the gene MAPT and Alzheimer disease.