XBP1 and vitiligo: One SNP in a CNE conserved in 14 of 15 avian species is predicted to result in loss of an XBP1 binding site upstream of EDNRB2. This is particularly relevant to piebalding as XBP1 is linked to pigment loss as a candidate gene for vitiligo in humans, and loss of a predicted XBP1 binding site near EDNRB2 is associated with plumage depigmentation in ducks [27,28].