Approximately, 75 to 80 percent of ME/CFS subjects appear to have an irritant rhinitis with increased mucin production [1, 2], and there appears to be a relationship between ME/CFS and dry eye syndrome [3, 4], with a previous clinical study demonstrating that sicca symptoms existed in about 70 percent of ME/CFS patients [4]. The gene discussed is MUC5AC; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.