HIVEP3 and osteogenesis imperfecta: We further find evidence that correcting these defects in the skeletal vascular microenvironment can ameliorate the OI phenotype, as SHN3-deficiency can rescue the Col1a2oim/oim model, correcting both the dysregulation in the SSC vascular niche and skeletal fragility in the Col1a2oim/oim model.