Blind docking challenges prior to AF, particularly CASP13-CAPRI and CASP14-CAPRI experiments, reported high-quality predictions for only 8% targets.7,8 With the availability of AF and AFm, the CASP15-CAPRI experiment stood as its first blind assessment for prediction of protein complexes and higher-order assemblies.9 In this round, the docking community relied on AF and AFm for single-structure or complex predictions. This evidence concerns the gene RASA4 and atrial fibrillation.