MXRA7 was highly expressed in childhood acute lymphoblastic leukemia (ALL) and ovarian endometriomas.7,8 At first, our laboratory found a dynamic change of MXRA7 mRNA in inflammatory corneal disease models in adult mice.9 Then, we investigated the biological functions of MXRA7 using other models and demonstrated that MXRA7 was related to matrix remodeling that affected tissue damage or regenerative processes.9–11 Recently, we also found that the function of BM mesenchymal stem cells was related with MXRA7.12 The gene discussed is MXRA7; the disease is acute lymphoblastic leukemia.