U2AF1 and myelodysplastic syndrome: In addition, m6A mRNA methylation was detected in 70 of 104 known MDS genes, including 8 of the 10 most commonly mutated genes (eg, RPS19, TET2, SF3B1, ASXL1, RUNX1, DNMT3A, ZRSR2, and STAG2).15 The U2AF1 S34F mutation exhibits lineage specificity in altering the pre-mRNA splicing of downstream target genes, resulting in distinct phenotypes in different myeloid lineages involved in MDS.88 Therefore, the study of post-transcriptional regulation in erythropoiesis is potentially important for understanding MDS and developing corresponding therapeutic strategies.