INSM1 and adenocarcinoma: We further characterized these different regions and observed a significant reduction of NEPC marker protein expression including ASLC1, INSM1, SYP, and CHGA and an increased level of the luminal epithelial marker cytokeratin-8 (CK8) in the sgCELSR3 adenocarcinoma regions compared with the NEPC regions or sgGFP tumors (Fig. 4B; Supplementary Fig. S3C).