To further characterize the molecular program associated with the CELSR3 KO and appearance of the CK8-positive, adenocarcinoma-like tumor foci, we performed LCM to specifically isolate adenocarcinoma-like cells in sgCELSR3 tumors or NEPC cells in control (sgGFP) tumors and performed whole transcriptome sequencing (RNA-seq). The gene discussed is KRT8; the disease is neoplasm.