In agreement with these data and the IHC data, we also found that epithelial markers KRT8, EPCAM, and CDH1 gene expression levels were upregulated while NEPC-associated genes INSM1, POU3F2 (encodes BRN2) and the neuronal gene OLIG2 were downregulated in sgCELSR3 adenocarcinoma-like cells compared with sgGFP NEPC cells (Fig. 4E). The gene discussed is INSM1; the disease is adenocarcinoma.