This process started with 66,235 protein coding gene transcript isoforms and after identifying 895 differentially expressed surface-associated gene transcript isoforms in NEPC compared with benign prostate tissue and that are not expressed in normal or prostate cancer tissues, we found that 28 gene transcript isoforms were overexpressed in NEPC compared with CRPC and which included a new transcript isoform encoded by the CDH2 gene (Fig. 1D). Here, CDH2 is linked to Familial prostate cancer.