Despite having reported to be increased in other skin conditions such as vitiligo and atopic dermatitis (Tamagawa-Mineoka et al., 2014; Vaccaro et al., 2016), IL-33 elevation was significantly higher in psoriatic than in AD lesions, hence lesional IL-33 seem to correlate strongly with psoriasis in a localized manner (Balato et al., 2012). This evidence concerns the gene IL33 and vitiligo.