Calcium-binding S100 proteins A8 (S100A8) and A9 (S100A9) levels were significantly increased in both serum and stratum corneum of psoriasis patients while also positively correlating with PASI scores (Benoit et al., 2006; Matsunaga et al., 2021), demonstrating the capability of these proteins in reflecting disease severity. The gene discussed is S100A8; the disease is psoriasis.