CTNNB1 and dengue disease: Approximately 85-90% of DF cases are sporadic and harbor a mutation of the gene encoding the beta catenin protein, CTNBB1; whilst the remaining 5-10% of DF harbor an APC gene mutation and arise in the context of Familial Adenomatous Polyposis Syndrome (FAP) or attenuated FAP syndrome (9, 10).