Activated B cell-like diffuse large B-cell lymphomas (ABC-DLBCL) depend on ‘chronic active’ BCR signaling which, similar to antigen (Ag) - dependent activation of normal B lymphocytes, engage multiple signaling cascades (10), as the MAPK, PI3K, NF-κB and NFAT networks. Here, BCR is linked to diffuse large B-cell lymphoma.