CD274 and prostate carcinoma: Prostate cancer also presents a lot of hypoxic zones, which seriously affect the antitumor function of T cells by a variety of mechanisms including the depletion of essential nutrients, abnormal angiogenesis, increased expression of adenosine, acidic pH, immunosuppressive transforming growth factor β (TGF β), and upregulation of PD-L1 (47, 48).