MUC16 and ovarian cancer: Besides, investigators found that LINE-1 ORF1p was observed in a wide range of ovarian cancer specimens and was present independently of human epididymal protein 4(HE4) and cancer antigen 125(CA-125), and they confidently detected ORF1p expression in biological fluids including ascites and plasma from ovarian cancer patients using Immuno multiple reaction monitoring-mass spectrometry (iMRM-MS) (74).