KDM4B and ovarian carcinoma: In addition, hypoxia-induced KDM4B is expressed in approximately 60% of epithelial ovarian cancer (EOC) and positively correlates with the tumor hypoxia marker CA-IX, which is strongly induced in EOC cell lines under hypoxic conditions, and inhibition of KDM4B expression can effectively control ovarian cancer cell invasion and migration in vitro (87).