Interestingly, hepatocellular carcinoma (HCC) also exhibits global DNA hypomethylation which increases genomic instability and rearrangements in HCC, allowing LINE-1 to insert into the c-MET gene and drive its transcription through a “copy-and-paste” mechanism, known as L1-MET, ultimately promoting the oncogenic pathway in HCC and leading to poor prognosis (41, 42). Here, MET is linked to hepatocellular carcinoma.