Furthermore, hypothalamic insulin resistance interferes with meal‐associated insulin effects on dopamine reuptake and the extinguishing of the hedonic system at the nucleus accumbens, causing a derangement of homeostatic feeding and promoting increased energy intake by way of reward‐induced (hedonic) overeating and addiction‐like eating behavior in a feed‐forward fashion.35, 36. The gene discussed is INS; the disease is Insulin resistance.