A+B+C: angiotensin-converting inhibitor + beta-blocker + calcium channel blocker; A+C+D: angiotensin-converting inhibitor + calcium channel blocker + diuretics; BP: blood pressure; FDTC: Family Drug Treatment Court; MACE: major adverse cardiovascular events; n: number; PAINT: Perindopril-Amlodipine plus Indapamide combination for controlled hypertension Non-intervention Trial; RAAS: renin-angiotensin-aldosterone system; RCT: randomized controlled trial; RH: resistant hypertension; SPC: single-pill combination; SR: sustained release; SBP: systolic blood pressure; DBP: diastolic blood pressure. This evidence concerns the gene REN and hypertensive disorder.