Tenocytes can be transformed from a quiescent state to an activated state by the inflammatory reaction of tendinopathy, being hypertrophic ones and highly expressing molecular markers such as toll-like receptor 4 (TLR4), interferon regulatory factor 1 (IRF1), IRF5, PDPN, CD106, and CD248 (Dakin et al., 2018). The gene discussed is IRF1; the disease is disease of the tendon.