Among them, TGF-β1 can upregulate the levels of Scleraxis (Scx) and Mohawk (Mkx) genes and induce tendonogenic differentiation of TSC, whereas TGF-β2 can stimulate collagen type I alpha 1 (COL1A1) and Scx gene expression (Zhang et al., 2018). The gene discussed is COL1A1; the disease is tuberous sclerosis.